Selective mediation of ovarian cancer SKOV3 cells death by pristine carbon quantum dots/Cu2O composite through targeting matrix metalloproteinases, angiogenic cytokines and cytoskeleton

Abstract It was shown that some nanomaterials may have anticancer properties, but lack of selectivity is one challenges, let alone selective suppression cancer growth by regulating the cellular microenvironment. Herein, we demonstrated for first time carbon quantum dots/Cu 2 O composite (CQDs/Cu O) selectively inhibited ovarian SKOV3 cells targeting microenvironment, such as matrix metalloproteinases, angiogenic cytokines and cytoskeleton. The result showed CQDs/Cu possessed properties against with IC 50 = 0.85 ?g mL ?1 , which approximately threefold lower than other tested 12-fold normal cells. Compared popular drugs, 114-fold 75-fold commercial artesunate (ART) oxaliplatin (OXA). Furthermore, ability to decrease expression MMP-2/9 induced alterations in cytoskeleton disruption F-actin. also exhibited stronger antiangiogenic effects inhibitor (SU5416) through down-regulating VEGFR2. In addition, has a vital function on transcriptional regulation multiple genes cells, where 495 were up-regulated 756 down-regulated. worth noting regulated angiogenesis-related Maspin TSP1 gene, suppress angiogenesis. Therefore, mediated death mainly decreasing MMP-2, MMP-9, F-actin, VEGFR2, meanwhile caused apoptosis via S phase cell cycle arrest. These findings reveal new application use potential therapeutic interventions